PT-141 (Bremelanotide) for Sexual Health
A therapy that works centrally — in the brain — to increase sexual desire in men and women.
PT-141 takes a different approach to sexual wellness: rather than acting on blood flow alone, it works on the brain pathways involved in desire.
What is PT-141?
Also known as bremelanotide, it’s a melanocortin receptor agonist that acts on the central nervous system.
How it works
It engages brain pathways involved in sexual arousal and desire — a central mechanism, distinct from medications that primarily affect blood flow.
What it’s used for
Low libido; sexual dysfunction.
Why patients choose it
It works centrally rather than just physically, and it can be effective for both men and women.
What to expect
Effects are typically felt within hours of use.
Safety & side effects
Nausea is among the more common effects; flushing or headache can occur. Suitability is reviewed individually.
Who is (and isn’t) a candidate
Determined by consultation, including a review of blood pressure and cardiovascular history.
Regulatory & sourcing status
Bremelanotide is FDA-approved (as Vyleesi) for hypoactive sexual desire disorder (HSDD) in premenopausal women. Use in men or for other purposes is off-label, and may involve compounded preparations; we’ll explain exactly what applies to you.
Last reviewed: 06/07/2026